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Bbb, Bilbo, and Drugs: INHIBIT CLASIFICATION ANTIBIOTICS Beta-Lactamase inhib Clavulanic Acid Penicinillase - Sensible Ampicillin Amoxicillin Aminopenicillins rum Natural Penicillins Penicillin G: Na, K, Procainic, Benzathine (IV, IM) Penicinillase - Resistant (very narrow spectrum) Antipseudomonal (extended spectrum) Penicillins (narrow spectrum) Penicillin VK: VO Oxacillin Dicloxacillin Carboxipenicillins Ureidopenicillins 1¬į Generation carcillin Carbenicillin Piperacillin Cephalexine Cephradrine Cefuroxime Cefadroxil Cefprozil Cefotetan 2¬į Generation Cefoperazone Ceftriaxone Cefpodoxime Ceftizoxime Ceftibuten Loracarbef Cefixime Cefotaxime Ceftazidime Cephalosporins 3¬į Generation Cefditoren Cefpirome* Ceftolozane 4¬į Generation Cefepime 5¬į Generation Carbapenems Monobactams Glycopeptides Meropenem Ertapenem DoripenemImipenem Cylastatine Aztreonam Telavancin Dalbavancin Oritavancin Isoniazid Vancomycin Daptomycin Gentamicin Neomycin Minocycline Demeclocylin* Tobramycin Amino glycosides Tetracyclins Streptomycin Doxycycline Tetracyclin Tigecyclirn Linezolid Oxazolidonones Streptogramins Quinupristin/Dalfopristin Cloramphenicol Macrolides Lincosamides 50S Erythromycin Azithromycin Clarithromycin Clindamycin Lincomycin DNA topoisomerases Moxifloxacin Ofloxacin Levofloxacin Enofloxacin Fluorquinolones Ciprofloxacin Norfloxacin Gemifloxacin Sparfloxacin Quinolones Nalidixic Acid Sulfonamides Sulfamethoxazole Ag Sulfadiazine Sulfasalazine Sulfisoxazole Trimethoprim (TMP) Metronidazole DHFR inhibitors Pyrimethamine DNA (damage) mRNA synth.Rifampim Nitroimidazoles <p><a href="http://mynotes4usmle.tumblr.com/post/94603349785/antibiotics-cheat-sheet-also-remember" class="tumblr_blog">mynotes4usmle</a>:</p> <blockquote><p><b>ANTIBIOTICS CHEAT SHEET :)</b></p> <p>Also, REMEMBER!!!!</p> <p><b>* Sulfonamides</b>¬†compete for albumin with:</p> <ul><li><b>Bilirrubin:¬†</b>given in 2¬į,3¬įT, high risk or indirect hyperBb and kernicterus in premies</li> <li><b>Warfarin:¬†</b>increases toxicity: bleeding</li> </ul><p>*¬†<b>Beta-lactamase (penicinillase) Suceptible:</b></p> <ul><li>Natural Penicillins (G, V, F, K)</li> <li>Aminopenicillins (Amoxicillin, Ampicillin)</li> <li>Antipseudomonal Penicillins (Ticarcillin, Piperacillin)</li> </ul><p>*¬†<b>Beta-lactamase (penicinillase) Resistant:</b></p> <ul><li>Oxacillin, Nafcillin, Dicloxacillin</li> <li>3¬įG, 4¬įG Cephalosporins</li> <li>Carbapenems¬†</li> <li>Monobactams</li> <li>Beta-lactamase inhibitors</li> </ul><p><b>* Penicillins</b>¬†enhanced with:</p> <ul><li><b>Clavulanic acid &amp; Sulbactam</b>¬†(both are suicide inhibitors, they inhibit beta-lactamase)</li> <li><b>Aminoglycosides</b>¬†(against enterococcus and psedomonas)</li> </ul><p>*¬†<b>Aminoglycosides¬†</b>enhanced with¬†<b>Aztreonam</b></p> <p><b>*</b>¬†Penicillins: renal clearance EXCEPT¬†<b>Oxacillin &amp; Nafcillin¬†</b>(bile)</p> <p><b>*</b>¬†Cephalosporines: renal clearance EXCEPT¬†<b>Cefoperazone &amp; Cefrtriaxone¬†</b>(bile)</p> <p>* Both inhibited by¬†<b>Probenecid</b>¬†during tubular secretion.</p> <p><b>* 2¬įG Cephalosporines:¬†</b>none¬†cross BBB except¬†<b>Cefuroxime</b></p> <p><b>* 3¬įG Cephalosporines:¬†</b>all cross BBB except¬†<b>Cefoperazone</b>¬†bc is highly highly lipid soluble, so is protein bound in plasma, therefore it doesn‚Äôt cross BBB.</p> <p><b>* Cephalosporines¬†</b>are¬†&quot;<b>LAME</b>‚Äú bc they¬†¬†do¬†<b>not cover</b>¬†this organisms¬†</p> <ul><li><b>L ¬†</b>isteria monocytogenes</li> <li><b>A ¬†</b>typicals (Mycoplasma, Chlamydia)</li> <li><b>M¬†</b>RSA¬†<b>(except Ceftaroline, 5¬įG)</b></li> <li><b>E¬†</b>¬†nterococci</li> </ul><figure class="tmblr-full" data-orig-height="282" data-orig-width="500" data-orig-src="https://78.media.tumblr.com/fefa0e57bd8663f41e32258e9f58f135/tumblr_inline_mvv7hx19421r9he9m.gif"><img src="https://78.media.tumblr.com/cdf6c898d35c4d91aa1f3e6bd9a98462/tumblr_inline_p7g6owpmSr1scxgwx_540.gif" alt="image" data-orig-height="282" data-orig-width="500" data-orig-src="https://78.media.tumblr.com/fefa0e57bd8663f41e32258e9f58f135/tumblr_inline_mvv7hx19421r9he9m.gif"/></figure><p>* Disulfiram-like effect:¬†<b>Cefotetan¬†</b>&amp;¬†<b>Cefoperazone¬†</b>(<i><b><a href="http://mynotes4usmle.tumblr.com/post/72610336163/drugs-that-cause-disulfiram-like-effects-mnemonic#.U98PPPl5Mms">mnemonic</a></b></i>)<b><br/></b></p> <p><b>* Cefoperanzone:¬†</b>all the exceptions!!!</p> <ul><li>All 3¬įG cephalosporins cross the BBB except Cefoperazone.</li> <li>All¬†cephalosporins are renal cleared, except Cefoperazone.</li> <li>Disulfiram-like effect</li> </ul><p>* Against¬†<b><i>Pseudomonas</i></b>:</p> <ul><li>3¬įG¬†<b>Cef taz idime¬†</b>(taz taz taz taz)</li> <li>4¬įG¬†<b>Cefepime, Cefpirome¬†</b>(not available in the USA)</li> <li><b>Antipseudomonal penicillins</b></li> <li><b>Aminoglycosides¬†</b>(synergy with beta-lactams)</li> <li><b>Aztreonam¬†</b>(pseudomonal sepsis)</li> </ul><p>* Covers¬†<b>MRSA:¬†</b><b>Ceftaroline¬†</b>(rhymes w/ Caroline, Caroline the 5¬įG Ceph),¬†<b>Vancomycin,¬†</b><b>Daptomycin,¬†</b><b>Linezolid,¬†</b><b>Tigecycline.</b></p> <p><b>*¬†</b>Covers¬†<b>VRSA: Linezolid, Dalfopristin/Quinupristin</b></p> <p><b>* Aminoglycosides:</b>¬†decrease release of ACh in synapse and act as a Neuromuscular blocker, this is why it enhances effects of muscle relaxants.</p> <p><b>* DEMECLOCYCLINE:¬†</b>tetracycline that‚Äôs not used as an AB, it is used as tx of SIADH to cause Nephrogenic Diabetes Insipidus (inhibits the V2 receptor in collecting ducts)</p> <p>* Phototoxicity:¬†<b>Q</b>¬†ue<b>¬†S T¬†</b>¬†ion?</p> <ul><li><b>Q¬†</b>uinolones</li> <li><b>S</b>ulfonamides</li> <li><b>T</b>¬†etracyclines</li> </ul><figure class="tmblr-full" data-orig-height="281" data-orig-width="500" data-orig-src="https://78.media.tumblr.com/7af835b2dc618c0aac3a1186d5ee68fb/tumblr_inline_n9rlcbPQ271r9he9m.gif"><img src="https://78.media.tumblr.com/7af835b2dc618c0aac3a1186d5ee68fb/tumblr_inline_p7g6owDZDE1scxgwx_540.gif" alt="image" data-orig-height="281" data-orig-width="500" data-orig-src="https://78.media.tumblr.com/7af835b2dc618c0aac3a1186d5ee68fb/tumblr_inline_n9rlcbPQ271r9he9m.gif"/></figure><p>* <b><a href="http://mynotes4usmle.tumblr.com/post/62061356766/cyp450-inducers-inhibitors-mnemonic#.U-RmDfl5Mms">p450 inhibitors</a>:</b> Cloramphenicol, Macrolides (except Azithromycin), Sulfonamides</p> <p>* <b>Macrolides SE: Motilin</b> stimulation, <b>QT prolongation</b>, reversible <b>deafness</b>, <b>eosinophilia</b>, <b>cholestatic</b> hepatitis</p> <p>*¬†<b>Bactericidal:¬†</b>beta-lactams (penicillins, cephalosporins, monobactams, carbapenems), aminoglycosides, fluorquinolones, metronidazole.</p> <p><b>* Baceriostatic:¬†</b>tetracyclins, streptogramins, chloramphenicol, lincosamides, oxazolidonones, macrolides, sulfonamides, DHFR inhibitors.</p> <p>*¬†<b>Pseudomembranous colitis:¬†</b>Ampicillin, Amoxicillin, Clindamycin, Lincomycin.</p> <p>*¬†<b>QT prolongation:¬†</b>macrolides, sometimes fluoroquinolones</p></blockquote>

mynotes4usmle: ANTIBIOTICS CHEAT SHEET :) Also, REMEMBER!!!! * Sulfonamides¬†compete for albumin with: Bilirrubin:¬†given in 2¬į,3¬įT, high ris...

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