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Drugs, Tumblr, and Cbs: Researchers fully 'delete' HIV from human cells for the first time BY STEVE DENT @STEVETDENT JUL 22ND 2014 6:28AM So far, HIV has eluded a cure because it installs its genome into human DNA so insidiously that it's impossible for our immune system to clear it out. While current treatments are effective, a lifetime of toxic drugs are required to prevent its recurrence. But researchers from Temple University may have figured out a way to permanently excise it using a highly-engineered HIV "editor." Here's how it works: the team analyzed a part of our immune system that fights infection and built a "guide RNA" strand consisting of 20 nucleotides (RNA building blocks). Those strands were then injected into cells typically infected with HIV, like T-cells. There, they targeted the end parts of the virus's gene and snipped out all 9,709 nucleotides that made up its genome. Since the guide RNA strand contained no human DNA sequences, it left the host cell intact- but free from HIV lanque-hates-terfs: allthingshyper: gehayi: hiddlesbatchlove: forever-falling-forward: platredeparis: bnycolew: mannysiege: Progress What Imma just let this sit here MOTHA FUCKIN SCIENCE sources: Engagdget DailyTech CBS They turned RNA into an anti-virus program. That is amazing. Let me restate this in case it didn’t sink in the first time Researchers physically DELETED ALL TRACES of the HIV virus from a human cell. ALL OF IT. IF YOU ARE NOT EXCITED ABOUT THAT I DON’T THINK YOU KNOW WHAT HIV IS YEAAAAAAHHHHH!
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Barcelona, Facts, and Family: 1346 Moscow Stockholm openhagen Kiey London ologne Cracow Vienna Paris Milan Constantinople Marsailles Rome Barcelona detenebrate: 0xymoronic: shitarianasays: theeyesinthenight: the-sonic-screw: platinumpixels: volpesvolpes: unseilie: sarahvonkrolock: gaysexagainstawall: them-days-was-olden-as-fuck: The spread of the black death. Poland Poland, tell us your secret. Poland is the old new Madagascar.  If I remember correctly, Poland’s secret is that the jews where being blamed all over europe (as usual) as scapegoats for the black plague. Poland was the only place that accepted Jewish refugees, so pretty much all of them moved there.  Now, one of the major causes of getting the plague was poor hygiene. This proved very effective for the plague because everyone threw their poop into the streets because there were no sewers, and literally no one bathed because it was against their religion. Unless they were jewish, who actually bathed relatively often. When all the jews moved to Poland, they brought bathing with them, and so the plague had little effect there. Milan survived by quarantining its city and burning down the house of anyone showing early symptoms, with the entire family inside it.  I reblogged this tons of times, but the Milan info is new. Damn Italy, you scary. Poland: “Hey, feeling a bit down? Have a quick wash! There, you see? All better” Milan: “Aw, feeling a bit sick are we? BURN MOTHERFUCKER, BURN!!!!!” Also, this might have something to do with it: from what I understand, O blood type is uncommonly… common in Poland. Something to do with large families in small villages and a LOT of intermarriage. The black plague was caused by a bacterium that produced, in its waste in the human body, wastes that very closely mimic the “B” marker sugars on red blood cells that keep the body from attacking its own immune system. Anyone who has a B blood type had an immune system that was naturally desensitized to the presence of the bacterium, and therefore was more prone to developing the disease. Anyone who had an O type was doubly lucky because the O blood type means the total absence of ANY markers, A or B, meaning that their bodys’ immune system would react quickly and violently against the invaders, while someone with an A may show symptoms and recover more slowly, while someone with B would have just died. Because O is a recessive blood type, it shows in higher numbers when more people who carry the recessive genes marry other people who also carry the recessive gene. Poland, which has a nearly 700 year history of being conquered by or partnering with every other nation in the surrounding area, was primarily an agricultural country, focused around smaller, farming communities where people were legally tied to, and required to work, “their” land, and so historically never “spread” their genes across a large area. The economy was, and had been, unstable for a very long period of time leading up to the plague, the government had been ineffective and had very little reach in comparison to the armies of the other countries around for a very very long time, and so its people largely remained in small communities where multiple generations of cross-familial inbreeding could have allowed for this more recessive gene to show up more frequently. Thus, there could be a higher percentage of O blood types in any region of the country, guaranteeing less spread of the illness and moving slower when it did manage to travel. Combine this with the fact that there were very few large, urban centers where the disease would thrive, and with the above facts, and you’ve got a lovely recipe for avoiding the plague. Interestingly enough, as a result from the plague, the entirety of Europe now has a higher percentage of people with O blood type than any other region of the world.  WHY IS THIS ALL SO COOL When Tumblr teaches you more about the plague than 12 years of school ever did. Just to throw a nod in, as a medieval historian, this is all credible, and is the leading theory as to the plagues effectiveness at this point. So. Enjoy your new knowledge!
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Fire, Friends, and Fucking: Missing her vaccinations? We are not vaccinating You know what is a good business? Teeny tiny baby coffins. You can get them in frog green or fire engine red. melrose1124: deadcatwithaflamethrower: gehayi: or a adinfinitumxx: appropriately-inappropriate: doyouthinkaboutme: memeguy-com: years later House is still as relevant as he ever was I wasn’t vaccinated and never got sick so And I swam and didn’t drown. Anecdotes aren’t evidence. The reason YOU specifically didn’t get sick is because of something called Mass Immunity. That means that since everyone ELSE is vaccinated (you’re welcome), there’s nowhere for the virus to establish a hold. That mass immunity is the only thing that keeps people who CANNOT vaccinate—like the immunocompromised—from catching it. The second that people stop vaccinating, that immunity disappears and the disease resurges, as is clear from the fact that the US is currently experiencing an epidemic of a disease that was projected to become extinct in our lifetimes. Get immunized. There’s no reason not to. Considering that there’s a whole host of people in my age range who weren’t vaccinated enough (even I was missing the second dose of MMR until recently) getting the measles and the mumps I think it’s ridiculous that we’re arguing over a life and death situation. Literally, do you want to live or die? Also, even if you weren’t vaccinated and never got sick–at least not visibly–that doesn’t preclude the possibility that you picked up a virus and passed it on without knowing it.  Maybe you had…oh, let’s say measles. But you had no symptoms. Or maybe you had a fever,  or sore eyes, or a harsh dry cough, but that was it. But nothing that said anything was seriously wrong. And in the meantime, you went about your business. Maybe you waited for a bus with an old man, or shared an aisle at the store with a pregnant woman and her wailing one-year-old, or attended a party with your friends.   And the disease you didn’t know you had? That passed on to the people you met, or to people that they met. The disease you didn’t know you had was passed to a friend at that party, and she passed it to her mother and father, they passed it to their workmates, and now two offices are sick with your measles. The old man you saw at the bus stop? He got pneumonia as a result of the measles you passed to him. The pregnant woman from the store? She miscarried. Her baby, who was too young to be vaccinated? She developed encephalitis and died.  You’re not the only one who’s being protected by your vaccination. You’re protecting everyone else as well. That’s the fucking POINT of vaccination. Anti-vaxxers are permenantly on my shit-list as irresponsible, selfish motherfuckers and they can leave my planet any time they like. Due to the anti-rejection medications for my heart transplant, I have a suppressed immune system. I can get sick very easily and it can be very harmful or fatal to me if I get sick. Point is: VACCINATE YOUR DAMN KIDS.
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9gag, Alive, and Being Alone: hou 300kcal 41,200 kcal TOmin +1200kcal RGER KIN 9GAG.COM Forever Alone with 9GAG.COM skeletonmug: duckbunny: kate-wisehart: drtanner-sfw: rikakuuma: vulnerate: the-exercist: dreamofunconsciousness: the-exercist: my-way-to-get-skinny: Still hungry? Absolutely! The average active adult needs 2,000 calories per day in order to function in a safe and healthy manner. If I’m active to the point where I consistently run 1+ hour every day, then it is far more likely that my caloric needs are around 2,400-2,500. Considering that, a meal of 1,200 calories would perfectly suit my needs. It would supply roughly half of my calorie requirements, which is a God-send since a fast food meal is relatively cheap. It’s a great value, especially if I don’t have much time to cook or have the resources to prepare my own meals! The average burger is going to supply me with significant protein and carbs. That’s exactly what I’d need in order to build more muscle and have enough energy to make it through a workout. Even the sugar within the meal can be beneficial in supplying me with a boost of energy and can stop me from feeling hungry for a prolonged period of time. Not half bad. Is this the most healthy meal known to man? Of course not. But it’s still a very reasonable deal and the calorie count is well within the average adult’s daily needs.  Don’t let calories scare you! You need them. If you were capable of burning off an entire meal within the hour, you’d probably be dead by now. 1200 empty calories in a meal next to no nutrition. all the calories are sugar and fat. that’s it. you’ll have no energy and have glucose spikes in your blood because the lack of fiber because of the lack of complex carbs. this is diabetes in a meal.  so no, you should not be hungry for diabetes Nutritionally, this BK meal contains roughly 28g of protein and 3g of dietary fiber. It potentially also includes 35% of our Vitamin C daily requirements, 2% Vitamin A, 12% calcium, and 27% iron. Of the 1,010 calories (that I could verify directly from the company’s nutritional information guide), only 410 are from fat. That isn’t a terribly significant amount of fat, in the long run, nor are the nutrients small enough to be viewed as negligible. Eating this will not cause you to get diabetes. Eating this meal is perfectly fine if you do have diabetes, as long as you are able to adjust your insulin intake accordingly. So don’t use an illness as your debate point - Diabetic people are not a prop. “So don’t use an illness as your debate point - Diabetic people are not a prop.” I want that and variations of that on t shirts. damn, man. Someone just got completely schooled by a nutritionist. THIS A GOOD POST I’ve reblogged this again but I feel like it needs to be SAID again. Also someone needs to please come drive me to burger king and buy me a burger. Pretty please? I am diabetic, and the only thing that would give me pause is the drink. If that’s a diet soda, then it’s all fine. I mean sure, white bread isn’t the best possible thing, but it is the kind I mostly eat, and fried potatoes are basically OK because they’re starch, not simple sugar. Fries and a burger are better for me and more predictable than fruit. Fruit is a wild gamble. This meal - assuming diet soda - is one I can dose for. (I am diabetic because autoimmune conditions run in my family, and my pancreas has been randomly targeted for death by my immune system. Diet didn’t cause it and couldn’t have prevented it. Do not tell me I’m sick because I eat wrong. I’m alive because I eat.) We also need to ditch the idea that there is any such thing as food that is just “empty calories”. Presumably what people mean by that is that the only nutritional value something gives you is it’s calorific content.  The only foods that do that are things that are literally pure sugar. If you are eating pure sugar then yes you are only getting calories in the form of short chain carbohydrates/sugars that are broken down into glucose quickly. But for some people and in some instances that’s not a bad thing.  “empty calories” aren’t morally or even nutritionally bad. Sometimes that’s what our body needs -  a quick injection of glucose and calories for energy. Honestly I would rather glug a glucose drink like lucozade than a high caffeine “energy drink” when I am tired and need a boost any day of the week. But when people apply the “empty calories” thing to actual foods that aren’t pure sugar it is just inaccurate and frustrating. I mean, let’s take a step up from pure sugar and mix it with a fat in order to make buttercream frosting. If you at a spoon full of that it wouldn’t be “empty calories”. Sure it is a high sugar content so you are getting a high number of calories per spoonful and they are short chain carbohydrates so it’s not lasting energy but it’s still vital energy. But you are also ingesting fat. Fat isn’t bad for you, we need fats in our diet. It’s not a “empty calorie” it’s a vital part of how our body works. OK let’s look at something more sensible, a burger bun. Just he bun mind you, not even a complete meal like a full on burger. Even white bread contains a lot of nutrients which are useful to your body. You are going to be getting a mixture of carbohydrates both short and long so your body will have ongoing energy. Even white flour contains some proteins and trace minerals such as iron. There’s small amounts of fat, and salt in there too. Certainly not an “empty calorie” - quite a lo of useful stuff for your body. But please for the love of fluffy kittens stop thinking that “calories” are discrete magical food particles which are in some way separate from the things which actually make up our food. Food is pretty complex and our bodies even more so. We need calories, we also make use of a lot of different things that are found in all sorts of food.  Remember that a calorie is a unit of measurement to show how much energy something produces. Calorie content is calculated literally by burning food. A calorie isn’t a nutrient in the same way as carbohydrates, proteins, amino acids, fats and minerals are. A food item isn’t made up of calories. It is made up of molecules of carbs, fats proteins and so on. It is the burning of those that gives us calorie content. If something has calories then it HAS to have other nutritional content in order to physically exist even if that content is just short chain carbohydrates.  Unless somebody is only eating pure sugar they aren’t eating “empty calories”. 

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Doctor, Facts, and Fucking: If you mixed Mercury. Aluminum phosphat Amonium sulfate, and Formaldehyde with VIRUSES then got a syringe and INJECTED it into your child you would be ARRESTED and sent to JAIL for child endangerment and abuse Then WHY is it legal for doctor to do it? and WHY would you let them? Educate yourself Re-Think Vaccines are the worst person You can be a vegan and whine at people, thats hurting nobody but when you tell people to not take vaccines, you're endangering public health. If YOU mixed formaldehyde and viruses and injected it into someone,you'd kill someone because you have no pharmacological experience. mercury, aluminium e, If someone in a lab mixed those together, they know how they work they have medically assessed and peer reviewed evidence and strict guidelines to follow to create a safe and effective product. Why is it legal? Because they know what they're doing and know how to spell phosphate" and "ammonium. Why dont YOU educate inst notion that all scientists are evil and want to poison you are your natural, vegan lifestyle. I say this as a fucking IMMUNOLOGIST, you are single handedly responsible for the skyrocketing resurgence of deaths caused by TB, measles and the worrying prospect of smallpox returning. te yourself instead of subscribing to the Let's break this one down and give you some education. compound thiomersal which was Mercury is an element in the part of many vaccines. It has been claimed with NO tangible evidence other than a multifaceted correlation that thiomersals cause autism. This has been investigated thoroughly and no causal link has been found. .Aluminium phosphate is an aluminium salt which is used as an adjuvant in vaccines. An adjuvant is a compound which causes an immune response to be higher and stronger, so that the immune system comes into contact with the attenuated virus more, so that it can recognise the antigens of the virus and provide immunity. They are a necessary part of the vaccine it you want it to work well. . Ammonium sulfate is used in the process of purifying the proteins in the synthesis of a vaccine. It is also found in bread and flour, so you'd better learn to enjoy rice if you want to avoid it. Formaldehyde is used in the treatment and purification of vaccines and stops contamination. Most of this is removed before the vaccines is shipped, although some remains. In my personal and scientifically backed opinion, the war against disease is a hundred fold more important than the mum-led war against vaccines. Do you want your child to die a slow, painful, agonising death? If not, then shut the fuck up with your so called facts" you got from Yahoo Answers and get your kid vaccinated. I am going to sound derogatory, but if you don't have formal education in at least biology, you have no role to talk about the way vaccines should be done. You have no idea of the actual function and mechanism in which they work, and you have is a vague knowledge that mercury used to make people mad, formaldehyde is used in embalming and that ammonium sulfate and aluminium phosphate sound scary Vaccinate your kids if you want them to live. End of. If you don't then you clearly don't love your kids and would prefer to see them die of completely preventable diseases. This has been a rage filled, alcohol induced response from a scientist. Antivaxxer just got schooled so hard they need an ICU
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