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Anaconda, Dude, and Facebook: did you know? did-you-kno.tumblr.com Jesus encouraged people not to pray out loud, and to practice their religion in private. did-you-kno.tumblr.com didyouknowblog.com facebook.com/didyouknowblog jathis: cerulean-tmp: nonespark: ask-gallows-callibrator: wintercoffin: brotoro: cherryblossomsparkle: did-you-kno: Source THIS IS ABSOLUTELY CORRECT ACTUALLY THIS MAKES ME REALLY HAPPY  he was 100% against preaching to unwilling people, too, and all for bringing religion into the lives of those who wanted it. he would often say that those who pray loudly in front of others were the worst kind of believers what a cool dude it makes me sad when people mischaracterize jesus like he was literally the nicest dude ever like he could be anyones bff if he tried because he was so rad like i hate christians who make him seem rude like lol no stopv YES YES YES. this is because the pharisees would go out into public, get on their knees, and pray where everyone could see them. because they wanted everyone to see how good they were and how pious, because they were sort of religious authority. but jesus came and told people to do the opposite, because he wanted them to be humble. because God wants you to be devoted to a relationship with Him, not to be devoted to making sure others think highly of you. jesus also encouraged people to do good deeds quietly, or even anonymously. because he wanted you to do good deeds for the sake of others, not for how good it’ll make you feel or for others to praise you. jesus was the absolute coolest and i fucking hate it when anyone points fingers at a certain group of people and says “GOD HATES-” NO HE DOESN’T. THAT WAS HIS WHOLE THING. HE LITERALLY LOVED EVERYONE. ???? This is the type of Christianity and Christians that I like. canon Jesus fanon Jesus
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Bbb, Bilbo, and Drugs: INHIBIT CLASIFICATION ANTIBIOTICS Beta-Lactamase inhib Clavulanic Acid Penicinillase - Sensible Ampicillin Amoxicillin Aminopenicillins rum Natural Penicillins Penicillin G: Na, K, Procainic, Benzathine (IV, IM) Penicinillase - Resistant (very narrow spectrum) Antipseudomonal (extended spectrum) Penicillins (narrow spectrum) Penicillin VK: VO Oxacillin Dicloxacillin Carboxipenicillins Ureidopenicillins 1° Generation carcillin Carbenicillin Piperacillin Cephalexine Cephradrine Cefuroxime Cefadroxil Cefprozil Cefotetan 2° Generation Cefoperazone Ceftriaxone Cefpodoxime Ceftizoxime Ceftibuten Loracarbef Cefixime Cefotaxime Ceftazidime Cephalosporins 3° Generation Cefditoren Cefpirome* Ceftolozane 4° Generation Cefepime 5° Generation Carbapenems Monobactams Glycopeptides Meropenem Ertapenem DoripenemImipenem Cylastatine Aztreonam Telavancin Dalbavancin Oritavancin Isoniazid Vancomycin Daptomycin Gentamicin Neomycin Minocycline Demeclocylin* Tobramycin Amino glycosides Tetracyclins Streptomycin Doxycycline Tetracyclin Tigecyclirn Linezolid Oxazolidonones Streptogramins Quinupristin/Dalfopristin Cloramphenicol Macrolides Lincosamides 50S Erythromycin Azithromycin Clarithromycin Clindamycin Lincomycin DNA topoisomerases Moxifloxacin Ofloxacin Levofloxacin Enofloxacin Fluorquinolones Ciprofloxacin Norfloxacin Gemifloxacin Sparfloxacin Quinolones Nalidixic Acid Sulfonamides Sulfamethoxazole Ag Sulfadiazine Sulfasalazine Sulfisoxazole Trimethoprim (TMP) Metronidazole DHFR inhibitors Pyrimethamine DNA (damage) mRNA synth.Rifampim Nitroimidazoles <p><a href="http://mynotes4usmle.tumblr.com/post/94603349785/antibiotics-cheat-sheet-also-remember" class="tumblr_blog">mynotes4usmle</a>:</p> <blockquote><p><b>ANTIBIOTICS CHEAT SHEET :)</b></p> <p>Also, REMEMBER!!!!</p> <p><b>* Sulfonamides</b> compete for albumin with:</p> <ul><li><b>Bilirrubin: </b>given in 2°,3°T, high risk or indirect hyperBb and kernicterus in premies</li> <li><b>Warfarin: </b>increases toxicity: bleeding</li> </ul><p>* <b>Beta-lactamase (penicinillase) Suceptible:</b></p> <ul><li>Natural Penicillins (G, V, F, K)</li> <li>Aminopenicillins (Amoxicillin, Ampicillin)</li> <li>Antipseudomonal Penicillins (Ticarcillin, Piperacillin)</li> </ul><p>* <b>Beta-lactamase (penicinillase) Resistant:</b></p> <ul><li>Oxacillin, Nafcillin, Dicloxacillin</li> <li>3°G, 4°G Cephalosporins</li> <li>Carbapenems </li> <li>Monobactams</li> <li>Beta-lactamase inhibitors</li> </ul><p><b>* Penicillins</b> enhanced with:</p> <ul><li><b>Clavulanic acid &amp; Sulbactam</b> (both are suicide inhibitors, they inhibit beta-lactamase)</li> <li><b>Aminoglycosides</b> (against enterococcus and psedomonas)</li> </ul><p>* <b>Aminoglycosides </b>enhanced with <b>Aztreonam</b></p> <p><b>*</b> Penicillins: renal clearance EXCEPT <b>Oxacillin &amp; Nafcillin </b>(bile)</p> <p><b>*</b> Cephalosporines: renal clearance EXCEPT <b>Cefoperazone &amp; Cefrtriaxone </b>(bile)</p> <p>* Both inhibited by <b>Probenecid</b> during tubular secretion.</p> <p><b>* 2°G Cephalosporines: </b>none cross BBB except <b>Cefuroxime</b></p> <p><b>* 3°G Cephalosporines: </b>all cross BBB except <b>Cefoperazone</b> bc is highly highly lipid soluble, so is protein bound in plasma, therefore it doesn’t cross BBB.</p> <p><b>* Cephalosporines </b>are &quot;<b>LAME</b>“ bc they  do <b>not cover</b> this organisms </p> <ul><li><b>L  </b>isteria monocytogenes</li> <li><b>A  </b>typicals (Mycoplasma, Chlamydia)</li> <li><b>M </b>RSA <b>(except Ceftaroline, 5°G)</b></li> <li><b>E </b> nterococci</li> </ul><figure class="tmblr-full" data-orig-height="282" data-orig-width="500" data-orig-src="https://78.media.tumblr.com/fefa0e57bd8663f41e32258e9f58f135/tumblr_inline_mvv7hx19421r9he9m.gif"><img src="https://78.media.tumblr.com/cdf6c898d35c4d91aa1f3e6bd9a98462/tumblr_inline_p7g6owpmSr1scxgwx_540.gif" alt="image" data-orig-height="282" data-orig-width="500" data-orig-src="https://78.media.tumblr.com/fefa0e57bd8663f41e32258e9f58f135/tumblr_inline_mvv7hx19421r9he9m.gif"/></figure><p>* Disulfiram-like effect: <b>Cefotetan </b>&amp; <b>Cefoperazone </b>(<i><b><a href="http://mynotes4usmle.tumblr.com/post/72610336163/drugs-that-cause-disulfiram-like-effects-mnemonic#.U98PPPl5Mms">mnemonic</a></b></i>)<b><br/></b></p> <p><b>* Cefoperanzone: </b>all the exceptions!!!</p> <ul><li>All 3°G cephalosporins cross the BBB except Cefoperazone.</li> <li>All cephalosporins are renal cleared, except Cefoperazone.</li> <li>Disulfiram-like effect</li> </ul><p>* Against <b><i>Pseudomonas</i></b>:</p> <ul><li>3°G <b>Cef taz idime </b>(taz taz taz taz)</li> <li>4°G <b>Cefepime, Cefpirome </b>(not available in the USA)</li> <li><b>Antipseudomonal penicillins</b></li> <li><b>Aminoglycosides </b>(synergy with beta-lactams)</li> <li><b>Aztreonam </b>(pseudomonal sepsis)</li> </ul><p>* Covers <b>MRSA: </b><b>Ceftaroline </b>(rhymes w/ Caroline, Caroline the 5°G Ceph), <b>Vancomycin, </b><b>Daptomycin, </b><b>Linezolid, </b><b>Tigecycline.</b></p> <p><b>* </b>Covers <b>VRSA: Linezolid, Dalfopristin/Quinupristin</b></p> <p><b>* Aminoglycosides:</b> decrease release of ACh in synapse and act as a Neuromuscular blocker, this is why it enhances effects of muscle relaxants.</p> <p><b>* DEMECLOCYCLINE: </b>tetracycline that’s not used as an AB, it is used as tx of SIADH to cause Nephrogenic Diabetes Insipidus (inhibits the V2 receptor in collecting ducts)</p> <p>* Phototoxicity: <b>Q</b> ue<b> S T </b> ion?</p> <ul><li><b>Q </b>uinolones</li> <li><b>S</b>ulfonamides</li> <li><b>T</b> etracyclines</li> </ul><figure class="tmblr-full" data-orig-height="281" data-orig-width="500" data-orig-src="https://78.media.tumblr.com/7af835b2dc618c0aac3a1186d5ee68fb/tumblr_inline_n9rlcbPQ271r9he9m.gif"><img src="https://78.media.tumblr.com/7af835b2dc618c0aac3a1186d5ee68fb/tumblr_inline_p7g6owDZDE1scxgwx_540.gif" alt="image" data-orig-height="281" data-orig-width="500" data-orig-src="https://78.media.tumblr.com/7af835b2dc618c0aac3a1186d5ee68fb/tumblr_inline_n9rlcbPQ271r9he9m.gif"/></figure><p>* <b><a href="http://mynotes4usmle.tumblr.com/post/62061356766/cyp450-inducers-inhibitors-mnemonic#.U-RmDfl5Mms">p450 inhibitors</a>:</b> Cloramphenicol, Macrolides (except Azithromycin), Sulfonamides</p> <p>* <b>Macrolides SE: Motilin</b> stimulation, <b>QT prolongation</b>, reversible <b>deafness</b>, <b>eosinophilia</b>, <b>cholestatic</b> hepatitis</p> <p>* <b>Bactericidal: </b>beta-lactams (penicillins, cephalosporins, monobactams, carbapenems), aminoglycosides, fluorquinolones, metronidazole.</p> <p><b>* Baceriostatic: </b>tetracyclins, streptogramins, chloramphenicol, lincosamides, oxazolidonones, macrolides, sulfonamides, DHFR inhibitors.</p> <p>* <b>Pseudomembranous colitis: </b>Ampicillin, Amoxicillin, Clindamycin, Lincomycin.</p> <p>* <b>QT prolongation: </b>macrolides, sometimes fluoroquinolones</p></blockquote>

mynotes4usmle: ANTIBIOTICS CHEAT SHEET :) Also, REMEMBER!!!! * Sulfonamides compete for albumin with: Bilirrubin: given in 2°,3°T, high ris...

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